Hexarelin is a synthetic growth hormone-releasing peptide (GHRP) that strongly stimulates GH secretion, even more potently than Ipamorelin or GHRP-6. Like Ipamorelin, it can be administered intranasally, though its effectiveness depends on formulation and absorption.
Key Facts About Hexarelin Nasal Spray
 
1. How It Works
Hexarelin is a ghrelin mimetic, binding to the GHS-R1a receptor to trigger GH release.
Unlike Ipamorelin, it has stronger GH-stimulating effects but may also slightly increase prolactin and cortisol (though less than GHRP-6).
Effects are dose-dependent, with rapid GH spikes (peaking around 15-30 mins after dosing).
 
2. Intranasal Absorption & Bioavailability
Possible but variable: Nasal peptides must be properly formulated for absorption.
Lower than injections: Likely requires higher doses than subcutaneous use.
Absorption enhancers (like chitosan or cyclodextrins) can improve uptake.
 
3. Benefits of Hexarelin Nasal Spray
✔ Stronger GH release than Ipamorelin (good for muscle growth & fat loss).
✔ Faster effects than injections (due to rapid nasal absorption).
✔ No needles—more convenient for frequent dosing.
✔ Anti-aging & recovery benefits (improved sleep, skin, joint repair).
 
4. Potential Side Effects
Increased hunger (due to ghrelin activation).
Mild cortisol/prolactin rise (less than GHRP-6).
Desensitization risk (long-term use may reduce effectiveness; cycling recommended).
Nasal irritation (if the spray contains harsh preservatives).
 
Hexarelin Nasal Spray vs. Injections
Feature
Nasal Spray
Subcutaneous Injection
Bioavailability
Lower (~30-50%?)
High (~90%+)
Dosing
200-600 mcg per spray
100-300 mcg per dose
Onset
Faster (15-30 mins)
Slower (30-60 mins)
Convenience
Easy, no needles
Requires injections
Side Effects
Possible nasal irritation
Injection site reactions
 
Dosing & Usage Guidelines
For Nasal Spray studies :
Typical dose: 200–600 mcg per spray (1–2x daily).
Best times:
Morning (fasted)
Pre-workout (for performance/recovery)
Before bed (to enhance sleep & GH pulse)
Cycle: 5 days on, 2 days off (to prevent desensitization).
For Injections studies
Typical dose: 100–300 mcg 1–2x daily.
 
✅ Hexarelin nasal spray can work if properly formulated, but it may require higher doses than injections.
🔥 Stronger than Ipamorelin but with slightly more side effects (hunger, possible cortisol rise).
⚠ Cycling is crucial (5 days on, 2 off) to avoid receptor desensitization.