SLU-PP-332: Current Research, Anecdotal Use, and Reviews
- joelstephen1940
- Jun 1
- 2 min read
What the Science Says
SLU-PP-332 is a first-in-class ERRα (Estrogen-Related Receptor Alpha) agonist, discovered by researchers at Saint Louis University. It mimics the effects of endurance exercise by boosting mitochondrial function, fat oxidation, and aerobic capacity.
Mechanism: Activates ERRα, a key regulator of mitochondrial biogenesis (similar to the effects of cardio training).
Animal Studies:
Mice given SLU-PP-332 showed 70% increased endurance (running time) without training.
Increased fat burning & reduced obesity in metabolic disease models.
Muscle fiber shifts toward slow-twitch (Type I), enhancing stamina.
No human trials yet – All data is from rodent studies (2021–2023).

How People Are Using It (Anecdotal Reports)
Since SLU-PP-332 is preclinical, human use is experimental and off-label. Early adopters (mostly biohackers and athletes) report:
• Dosing:
o 0.1–0.3 mg/kg body weight (some extrapolating from mouse studies).
o Example: A 70 kg (154 lb) person might try 7–21 mg per dose.
o Frequency: 2–3x/week (half-life is unclear in humans).
• Stacking:
o With cardarine (PPARδ agonist) for enhanced endurance.
o With AMPK activators (e.g., berberine, AICAR) for fat loss.
• ROA (Route of Administration):
o Most use subcutaneous (SubQ) or intramuscular (IM) injections (oral bioavailability unknown).
📊 Anecdotal Reviews & Effects
From early user reports (Reddit, forums, biohacker communities):
✅ Reported Benefits:
• Increased endurance (longer workouts, less fatigue).
• Fat loss (especially visceral fat, like Cardarine).
• Improved recovery (less DOMS after training).
• Mental clarity (ERRα is also active in the brain).
❌ Reported Side Effects:
• Heart palpitations (ERRα is highly expressed in cardiac muscle).
• Insomnia (if dosed too late in the day).
• Unknown long-term risks (no human toxicity studies).
⚠️ Major Risks & Unknowns
1. Cardiac Stress – ERRα activation could overwork the heart (risk of hypertrophy or arrhythmia).
2. Cancer Concerns – ERRα is upregulated in some cancers (breast, prostate).
3. No Human Safety Data – Dosing is purely speculative.
Future Potential
If human trials confirm safety, SLU-PP-332 could be a game-changer for:
• Metabolic diseases (obesity, diabetes).
• Age-related muscle loss (sarcopenia).
• Athletic performance (endurance sports).
Bottom Line
• Promising but highly experimental – Only for those comfortable with self-experimentation.
• Start low (≤10 mg/dose) and monitor heart rate/side effects.
• Not a substitute for exercise (but could help those unable to train).
Next a look into Fast twitch muscle fiber type II muscle for speed and explosiveness
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