DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that regulates sleep, reduces stress, and supports natural melatonin production. Originally isolated from rabbit brains, it has been studied for its ability to improve deep sleep, reset circadian rhythms, and lower cortisol.
Nasal spray delivery of DSIP is gaining popularity due to its potential for direct brain absorption, bypassing the digestive system and possibly enhancing bioavailability compared to injections.
 
1. How DSIP Nasal Spray Works
Mechanism of Action:
Stimulates delta-wave sleep (deep, restorative sleep)
Modulates cortisol (reduces stress-related insomnia)
Enhances melatonin secretion (without supplementation)
May have neuroprotective & anti-addictive effects (anecdotal reports)
Nasal Absorption Benefits:
Potential faster brain uptake via olfactory/trigeminal pathways
Avoids first-pass liver metabolism (unlike oral peptides)
 
2. DSIP Nasal Spray Dosage & Protocol
Since DSIP is not FDA-approved, dosing is based on research studies, biohacker reports, and peptide clinic protocols.
Common Dosage Ranges:
Form
Dosage
Frequency
Cycle Length
Nasal Spray
50–200 mcg (0.05–0.2 mg)
1x nightly (before bed)
10–30 days
Subcutaneous Injection
100–300 mcg/day
1x nightly
10–20 days
IV/IM (Rare)
Up to 500 mcg
Clinics only
Short-term
Typical Nasal Spray Protocol:
100 mcg per spray (1 spray per nostril = 200 mcg total)
Taken 30–60 mins before bedtime
Used for 10–30 days, then take a break (to avoid tolerance)
 
3. Effectiveness: Nasal vs. Injection
Factor
Nasal Spray
Injection
Bioavailability
~30–50% (estimated)
~70–90%
Onset of Effects
Faster (15–30 mins)
Slower (30–60 mins)
Convenience
No needles
More precise dosing
Reported Effects
Mild to moderate
Stronger (studies)
Conclusion:
Nasal spray is better for convenience and quick effects.
Injection may be more reliable for severe insomnia.
 
4. Benefits of DSIP
Deeper, more restorative sleep (increases delta waves)
Reduces nighttime cortisol (helps stress-related insomnia)
Non-habit forming (unlike prescription sleep aids)
May improve mood & recovery (anecdotal reports)