Epithalon nasal spray delivery
 
Epithalon (or Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) with potential anti-aging and telomere-stabilizing properties, originally derived from the pineal gland peptide Epithalamin. Nasal spray delivery of Epithalon is an emerging method of administration due to its potential for improved bioavailability and convenience compared to injections.
Benefits of Nasal Spray Delivery for Epithalon
Enhanced Bioavailability – The nasal mucosa has a rich blood supply, allowing peptides to bypass first-pass metabolism in the liver, leading to better absorption than oral administration.
Non-Invasive – Avoids the discomfort and risks associated with injections.
Rapid Absorption – The peptide can reach systemic circulation quickly, potentially leading to faster effects.
Improved Compliance – Easier and more convenient for regular use.
Key Considerations for Epithalon Nasal Spray
Dosage: Typical doses in research settings range from 1-5 mg per day, but optimal dosing for nasal delivery is not yet well-established.
Formulation: Requires proper solubility (usually in bacteriostatic water or saline) and may benefit from absorption enhancers (e.g., chitosan) to improve mucosal uptake.
Stability: Peptides can degrade quickly; preservatives or refrigeration may be needed.
Side Effects: Generally well-tolerated, but nasal irritation or mild immune reactions are possible.
Potential Applications
Anti-Aging: May support telomere maintenance and cellular longevity.
Neuroprotection: Possible cognitive benefits due to pineal gland modulation.
Metabolic & Immune Support: Some studies suggest effects on melatonin pathways and antioxidant activity.
Challenges & Research Status
Limited clinical trials on nasal delivery; most data comes from animal or in vitro studies.
Regulatory status varies by country (often sold as a research chemical, not FDA-approved for human use).