Ipamorelin is a synthetic peptide that acts as a selective growth hormone secretagogue (GHS), meaning it stimulates the release of growth hormone (GH) from the pituitary gland without significantly affecting cortisol or prolactin levels. It is often used for its potential anti-aging, muscle-building, and recovery-enhancing effects.
 
Key Considerations
Bioavailability
Nasal sprays offer a non-invasive route of administration, but the bioavailability (amount absorbed into the bloodstream) of peptide nasal sprays can vary. Some studies suggest nasal peptides may have lower absorption compared to subcutaneous injections but can still be effective if formulated correctly.
 
Dosing
Typical study dosages for Ipamorelin vary depending on the form (injection vs. nasal).
For nasal sprays, doses often range between 200–500 mcg per spray, taken 1–3 times daily.
Always follow the manufacturer's guidelines or a healthcare provider's advice.
 
Benefits
Increased GH secretion → potential muscle growth, fat loss, and improved recovery.
May enhance sleep quality and skin health.
Less risk of side effects compared to non-selective GH secretagogues (like GHRP-6).
 
Possible Side Effects
Mild hunger increase (due to ghrelin-receptor activity).
Rare: headache, dizziness, or flushing.
Long-term safety data is limited (use under medical supervision if possible).
 
Comparison to Other Forms
Subcutaneous Injection – Higher bioavailability but requires needles.
Oral Peptides – Usually ineffective due to digestion.
Nasal Spray – More convenient but may require higher doses for similar effects.