Selank spray delivery

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a modified analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg).

The modification—the addition of a C-terminal Pro-Gly-Pro tripeptide—significantly enhances its metabolic stability in the bloodstream and central nervous system, prolonging its biological activity in research models.

Chemically, it is classified as a anxiolytic and nootropic peptide and is noted for its lack of sedative, muscle-relaxant, or amnesic side effects in animal studies, which distinguishes it from classical benzodiazepines.

From a research perspective, Selank is a prototype "smart" anxiolytic peptide that demonstrates how a single molecule can simultaneously modulate neural, endocrine, and immune systems to produce a balanced behavioral effect—reducing anxiety and improving stress resilience while preserving or enhancing cognitive function. It serves as a critical model for studying integrated brain-body pathways in emotional regulation.