Pinealon Nasal Spray Delivery
Pinealon (also spelled Pinealone) is a synthetic tripeptide (Lys-Glu-Asp) with neuroprotective, anti-aging, and cognitive-enhancing effects. Originally developed in Russia, it is used to slow brain aging, improve memory, and support neuronal repair.
Nasal spray delivery is gaining interest because of its direct pathway to the brain (via the blood-brain barrier and olfactory nerves), potentially enhancing bioavailability compared to oral or injectable routes.
 
1. How Pinealon Nasal Spray Works
Mechanism:
Reduces oxidative stress in neurons
Enhances neuroplasticity (learning & memory)
May stimulate telomerase activity (anti-aging effect)
Modulates glutamate receptors (neuroprotection)
Nasal Absorption Benefits:
Bypasses the digestive system
May reach the brain faster than injections (intranasal peptides can enter via the olfactory or trigeminal nerve pathways)
2. Pinealon Nasal Spray Dosage & Protocol
Since Pinealon is not FDA-approved, dosing is based on Russian clinical studies, biohacker reports, and peptide clinic protocols.
Common Dosage Ranges:
Form
Dosage
Frequency
Cycle Length
Nasal Spray
100–300 mcg (0.1–0.3 mg)
1–2x daily
10–30 days
Subcutaneous Injection
2–5 mg/day
1x daily
10–20 days
Oral (Less Effective)
5–10 mg/day
1–2x daily
Low absorption
Typical Nasal Spray Protocol:
100–200 mcg per spray (1 spray per nostril, 1–2x daily)
Used for 10–30 days, followed by a break (to prevent receptor desensitization)
Best taken in the morning or before cognitive work
 
3. Effectiveness: Nasal vs. Injection
Factor
Nasal Spray
Injection
Bioavailability
~30–50% (estimated)
~80–100%
Brain Uptake Speed
Faster (direct pathway)
Slower (systemic)
Convenience
No needles
Requires injections
Reported Effects
Subtle but noticeable
Stronger (studies)
 
Nasal spray is more convenient for daily cognitive support.
Injection may be better for stronger neuroprotective effects (e.g., post-stroke recovery).
 
4. Benefits of Pinealon
Anti-brain aging (may slow cognitive decline)
Memory & focus improvement (anecdotal reports)
Neuroprotection after injury/stroke (Russian studies)
Mild anti-anxiety & mood stabilization
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